Relationship between endothelin-1 and nitron oxygen changes in cerebral spinal fluid and cerebral vasospasm following subarachnoid hemorrhage
- VernacularTitle:蛛网膜下腔出血后脑脊液中内皮素-1和一氧化氮变化与脑血管痉挛的关系
- Author:
Qinghai HUANG
;
Jianmin LIU
;
Tao XIN
- Publication Type:Journal Article
- Keywords:
Subarachnoid hemorrhage;
Cerebral vasospasm;
Endothelin-1;
nitric oxygen
- From:Journal of Interventional Radiology
2003;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between endothelin-1(ET-1)and NO in cerebral spinal fluid(CSF) and cerebral vasospasm(CVS) following experimental subarachnoid hemorrhage(SAH).Methods An experimental CVS model was achieved by twice injections of fresh autologous arterial blood into the cisterna magna of each animal. The contents of ET-1 and NO in CSF were measured by radioimmunological analysis and activated cadmium reduction method respectively.The degrees of CVS were analyzed through cerebral angiography(%reduction of basilar artery diamiter,%RBAD). Results The contents of ET-1 in CSF increased significantly than that before injection after SAH(P
