Combination treatment in acute myocardial infarction-thrombolysis and immediate early PTCA in acute myocardial infarction
- VernacularTitle:急性心肌梗死药物溶栓后早期介入治疗
- Author:
Ming ZHANG
;
Zhangquan LI
;
Long YUAN
- Publication Type:Journal Article
- Keywords:
Acute myocardial infarction;
Recombind tissue-type plasminogen activator
- From:
Journal of Interventional Radiology
2004;0(S2):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The study evaluated the efficiency and safety of a short-acting full-dose fibfinolytic regimen to promote early infarct-related artery (IRA) patency during the inherent delay experienced by infarction patients referred for angioplasty as the principal recanalization modality. Method Accepted aspirin and heparin, 75 patients were treated by an intravenous bolus of 20 mg recombined tissue-type plasminogen activator (rt-PA), then followed by 80 mg over 30 minutes. Patients were to undergo angiography as soon as possible following study drug. If the IRA was occlude (TIMI flow grade 0 or 1),or was open but with ≥50% stenosis, immediate early PTCA at the same time. The end point included patency rates on catheterzation laboratory (cath Lab) arrival, technical results when PTCA was performed, complication rates, clinical adverse events rates and left ventricular (LV) function by treatment assignment in two weeks. Results Patency on Cath lab arrival was 88% with combination treatment group (26% Thrombolysis in myocardia infarction trial TIMI-2, 66%TIMI-3), and 36%with primary PTCA group (20%TIMI-2, 16%TIMI-3), (P
