The clinical analysis of the urinary mycoplasma infection in patients with systemic lupus erythematosus
- VernacularTitle:系统性红斑狼疮伴尿路支原体感染的临床分析
- Author:
Jieping PAN
;
Yahua LU
;
Yingchun MA
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus, systemic;
Urethra;
Mycoplasma infections
- From:
Chinese Journal of Rheumatology
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the urinary tract infection by Mycoplasma in systemic lupus erythematosus (SLE) patients. Methods Mycoplasma hominis (Mh) and Ureaplasma urealyticum (Uu) from serum, eye, pharynx and urethra secretions were detected by nested polymerase chain reaction (nPCR) in 129 SLE patients, and DNA sequences of positive product were detected and analysed. Results Seventy-nine were positive and 50 were negative, 50 of 79 positive subjects (63.2%) were urinary tract infection, and 11 of 50 negative subjects (22.0%) were infected (P=0.001). Ninty-five active SLE patients, 66(69%) were positive and 29(30.5%) were negative for mycoplasma infection. Thirty-four inactive SLE patients, 13(38%) were positive and 21(61.7%) were negative for mycoplasma infection (P=0.000). Comparing these two setsof patients, the urinary tract infection in the active SLE was significantly higher than in stable patients. Conclusion Mycoplasma infection is the major pathogen inducing SLE flare and may be one of the infective pathogene of SLE.
