Serological Studies on Biejia Jian Decoction in Counteracting Hepatic Fibrosis
- VernacularTitle:鳖甲煎汤抗肝纤维化的血清学研究
- Author:
Weihong KUANG
- Publication Type:Journal Article
- Keywords:
HEPATITIS B, CHRONIC/complications;
LIVER CIRRHOSIS/TCD therapy;
BIEJIA JIAN DECOCTION/therapeutic use;
TRANSFORMING GROWTH FACTOR ? /blood;
TUMOR NECROSIS FACTOR/blood;
LIPID PEROXIDATION/blood;
SUPEROXIDE DISMUTASE/blood
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the effect of Biejia Jian Decoction on serum transforming growth factor ?1 (TGF-pl) , tumor necrosis factor a (TNF-?), lipid peroxidation ( LPO) and superoxide dismutase ( SOD) in patients with hepatic fibrosis (HF) induced by chronic hepatitis B. Its effect was compared with lamivudine. [Methods] Fifty-three cases of HF were randomized to two groups: group A (n = 27) was treated with Biejia Jian Decoction and group B ( n -26) with lamivudine for oral use. Twenty volunteers served as the normal controls (group C) . Serum levels of TGF-?1, TNF-?, LPO and SOD were observed before and after treatment. [Results] After treatment, serum levels of TGF-?1 and TNF-a were decreased markedly in group A (P 0.05) . Serum LPO level was lower and SOD level higher in groups A and B than those in group C before treatment ( P 0.05) but the level in group B differed from that of groups A and C (P 0.05) but the level in group B did not decrease and differed from that of groups A and C ( P
