Efficacy of Xiangsha Yangwei Wan in Inhibiting Side Effects due to Chemotherapy in Upper Digestive Tract
- VernacularTitle:香砂养胃丸对化疗所致上消化道副作用的抑制作用
- Author:
Weikua ZHENG
;
Lizhu LIN
;
Shude CHEN
;
Feng ZHAN
;
Jiaqi RAO
;
Derong XIE
;
Mingzhi HAO
- Publication Type:Journal Article
- Keywords:
NEOPLASM /drug therapy;
DRUG THERAPY/side effects;
GASTRITIS/TCD therapy;
XIANGSHA YANGWEI WAN/ therapeutic use
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the efficacy of Xiangsha Yangwei Wan (XYW) on the inhibition of chemotherapy-induced chemical gastritis and upper gastrointestinal symptoms. [Methods] A randomized controlled trial (RCT) was carried out in 87 cases of maligant tumor confirmed by histopathological and cytological examination. All the cases were treated with chemotherapy regimen of adriamycin ( ADM) , adcarbazine ( DTIC) , platinum-based agents, irinotecan (CPT-11) and fluorouraeil (5-FU). Meanwhile, 41 cases in group A were also treated with dexamethason and 5-HT3 receptor antagonist as an essential anti-emesis and with XYW to regulate gastrointestinal function; other 46 cases in group B were given dexamethason and 5-HT3 receptor antagonist only. Seven days after treatment, incidences of chemical gastritis and upper gastrointestinal symptoms were observed and compared between the two groups. [Results] Seven days after chemotherapy, upper gastrointestinal symptoms and signs were relieved in 95.1% (39/41) of the patients of group A and in 76.1 % (35/46) of group B; the occurring rate of chemical gastritis with symptoms was 2.4% (1/41) in group A and 19.6% (9/46) in group B, the differences being significant statistically between the two groups( P - 0.0122) . [ Conclusion ] XYW has an inhibitory effect on chemotherapy-induced chemical gastritis and upper gastrointestinal symptoms.