Docetaxel-loaded nanoformulation based on star-shaped M-PLGA for cervical cancer therapy
10.3760/cma.j.issn.1673-4181.2014.01.001
- VernacularTitle:星型M-PLGA纳米药物制剂用于宫颈癌治疗的研究
- Author:
Yichen DONG
;
Xiaowei ZENG
;
Wei TAO
;
Yongfeng GAO
;
Lin MEI
;
Laiqiang HUANG
- Publication Type:Journal Article
- Keywords:
Star-shaped copolymer;
Docetaxel;
Nanoparticles;
Drug delivery
- From:
International Journal of Biomedical Engineering
2014;37(1):1-5,后插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective Mannitol-poly(D,L-lactide-co-glycolide) (M-PLGA),a star-shaped biodegradable polymer,was synthesized with the intent in this research,to provide novel nanoformulation for cervical cancer chemotherapy.Methods The novel star-shaped copolymer was prepared by ring-opening polymerization,and characterized by NMR.The docetaxel-loaded M-PLGA nanoparticles,prepared by modified nano-precipitation method,were observed to be near-spherical shape with narrow size distribution.Results The CLSM results showed the uptake level of M-PLGA NPs was higher than PLGA NPs in Hela cells.A significantly higher level of cytotoxicity was achieved by docetaxel-loaded M-PLGA NPs than that of commercial Taxotere and docetaxel-loaded PLGA NPs,indicating that the star-shaped biodegradable polymer M-PLGA could be superior to the linear polymer PLGA as a drug carrier.The study on drug loading and encapsulation efficiency also proved that star-shaped M-PLGA could carry higher level of drug than linear polymer,therefore could be more efficient for cancer treatment.Conclusions In conclusion,the star-shaped M-PLGA copolymer may be used as a potential and promising drug-loaded biomaterial applied in developing novel nanoformulations for cervical cancer therapy.
