Effects of Extracts of Ginkgo Leaves on the Experiment Myocardial Ischemia and Blood Hemorheology
- VernacularTitle:银杏酮酯对实验性心肌缺血和血液流变性的影响
- Author:
Yun WEI
;
Aiping WU
;
Lan JI
;
Caihong HUANG
;
Linli SONG
- Publication Type:Journal Article
- Keywords:
Extract of ginkgo leaves;
Myocardial infarction;
Myocardial ischemia;
Blood hemorheology
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of extracts of ginkgo leaves (EGL) on acute myocardial infarction, acute myocardial ischemia and blood hemorheology.Methods The effects of EGL on acute myocardial infarction were observed in dogs model induced by the ligation of anterior descending branch of left coronary artery; effects on acute myocardial ischemia were observed on rats model caused by intravenous injection of pituitrin and effects on blood hemorheology were observed in rabbits. Results EGL significantly reduced the myocardial infarction area, decreased the activities of lactate dehydrogenase and creatine phosphokinase in dogs, reduced the elevation of ST segment of electrocardiogram in rats with myocardial ischemia and decreased whole blood viscosity and plasma viscosity in rabbits. Conclusion EGL has protective effect against myocardial ischemic injury and can improve the parameters of blood hemorheology in rabbits. Its mechanism may be concerned with the reduction of the myocardial infarction area and infarction degree and the relief of acute myocardial ischemia.
