The expression of VEGF-C and VEGFR-3 and the correlation with the lymphnode metastasis in esophagus squamous cell carcinoma
- VernacularTitle:食管鳞状细胞癌VEGF-C、VEGFR-3的表达及其与淋巴结转移的关系
- Author:
Youde CAO
- Publication Type:Journal Article
- Keywords:
Esophagus squamous cell carcinoma;
Vascular endothelial growth factor-C(VEGF-C);
Vascular endothelial growth factor receptor-3(VEGFR-3)
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of vascular endothelial growth factor-C(VEGF-C) and vascular endothelial growth factor receptor 3(VEGFR-3)and the correlation with the lymph node metastasis in esophagus squamous cell carcinoma.Methods:72 esophagus squamous cell carcinoma cases with complete clinical,pathological and following-up data were included in this study.Immunohistological method SABC was used to detect the expression of VEGF-C and VEGFR-3.Results:(1)The VEGF-C positive rate in esophagus squamous cell carcinomas is 59.72%(43/72).The mean number of VEGFR-3 vessel in VEGF-C positive group is 5.02?2.24 per high power field(HPF),while is 2.82?0.16 per HPF in VEGF-C negative group.The former is significantly higher than the later ( P
