Study of relationship between MUC1 and adhesion of breast cancer cells
- VernacularTitle:MUC1与人乳腺癌细胞粘附能力关系的体外研究
- Author:
Li LU
- Publication Type:Journal Article
- Keywords:
MUC1;
Glycosylation;
Benzyl-?-GalNAc;
Breast cancer cell line;
Adhesion
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of benzyl-?-GalNAc on MUC1 expression and the adhesion of breast cancer cell Iine(MDA-MB-231) so as to understand the relationship between MUC1 and invasiveness of human breast cancer cells.Methods:The activity and expression of MUC1 in breast cancer cells were detected with immunohistochemistry.The adhesive ability of those cells to various basement membrane components were measured by MTT assay.Results:Benzyl-?-GalNAc significantly suppressed the expression of MUC 1 and the adhesion of the tumor cell to basement membrane( P
