Expression and significance of survivin in human breastinfiltrating duct carcinoma
- VernacularTitle:Survivin在人乳腺浸润性导管癌中的表达及意义
- Author:
Yinbin MA
- Publication Type:Journal Article
- Keywords:
Survivin;
Breast neoplasms;
In situ hybridization;
Immunohistochemistry
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression and significance of survivin in human breast infiltrating duct carcinoma.Methods:In twenty-eight samples of human breast infiltrating duct carcinoma without chemotherapy,seventeen human breast infiltrating duct carcinoma with chemotherapy,fifteen human normal breast tissue adjacent to carcinoma,twenty breast benign lesion the expressions of survivin were determined by methods of in situ hybridization and immunohistochemistry.Results:The expressions of survivin mRNA were positively correlated with that of survivin protein in every marker and showed no significant difference.The positive expressions of survivin in human breast infiltrating duct carcinoma without chemotherapy were impressively high and they were significantly different among the ages,TNM stages,pathology grades,lymph node metastases and types of receptors( P
