The expression and significance of MRP and LRP in carcinoma of large intestine
- VernacularTitle:大肠癌组织中肺耐药蛋白和多药耐药相关蛋白的表达及临床病理意义
- Author:
Wenjun LUO
- Publication Type:Journal Article
- Keywords:
Large intestine neoplasms;
Drug resistance;
Multidrug resistance-associated protein;
Lung resistance protein
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression and clinical significance of MRP and LRP in carcinoma of large intestine.Methods:Immunohistochemistry is used to examine the MRP and LRP expression in 60 cases of large intestine carcinoma and 10 cases of normal large intestine tissues.Results:The positive expression rates of MRP and LRP in the 60 cases of large intestine carcinoma are 68.3% and 70% respectively and are all significantly higher than those in normal large intestine tissues ( P 0.05).Conclusion:MRP and LRP are both highly expressed in large intestine carcinoma and play an important role in the primary multidrug resistence(MDR) of large intestine carcinoma.
