The expression and significance of hepatocytegrowth factor and c-Met receptor in endometrial carcinoma
- VernacularTitle:肝细胞生长因子及其受体在子宫内膜癌组织中的表达及其意义
- Author:
Lin XIAO
- Publication Type:Journal Article
- Keywords:
Endometrial carcinoma (EC);
Hepatocyte growth factor (HGF);
Immunohistochemistry
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression and significance of hcpatocyte growth factor (HGF) and c-Met,receptor (c-Met) in endometrial carcimoma.Methods:Using S-P immunohistochemistry method,the expression of HGF and c-Met in the specimens of 52 cases with endometrial catcmoma and 16 cases with normal endometrium was examined.Then the correlation was analyzed between the two factors and the stage and differentiation of EC.Results:The expressions of HGF and c-Met in endometrial carcinoma were significantly higher than in normal endometrium.The expression of c-Met was closely associated with the stage and differentiation of endometrial carcinoma.Conclusion:Overexpression of HGF and c-Met facilitates the malignant progress of endometrium,c-Met is associated with the prognosis of EC.
