Alkaloid constituents from root of Aconitum coreanum
- VernacularTitle:黄花乌头中生物碱类化学成分的研究
- Author:
Chunhua YANG
;
Hanjie ZHANG
;
Jinghan LIU
- Publication Type:Journal Article
- Keywords:
Aconitum coreanum (L?vl.) Rapaics;
diterpenoid alkaloid;
guan-fu base P
- From:
Chinese Traditional and Herbal Drugs
1994;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To search for more bioactive alkaloids from Aconitum coreanurn through this fur-ther study. Methods The ethanolic extract from the root of A. coreanum was isolated by aluminium oxidecolumn chromatography, the constituent structures were elucidated mainly by their physicochemical prop-erties and spectroscopic (IR, ESI-MS,1 H-NMR, 13 C-NMR,1 H-1 HCOSY, HMQC, and HMBC)analysis.Results Seven alkaloids were obtained from the root of A. coreanum, they were identified as: 11, 13-di-acetyl-14-hydroxy-2-isobutyryl hetisine ( Ⅰ ), guan-fu base G ( Ⅱ ), guan-fu base F ( Ⅲ ), guan-fu base Z( Ⅳ ), guan-fu base I ( Ⅴ ), guan-fu base K ( Ⅵ ), and guan-fu aminealcohol (Ⅶ). Conclusion Compound I is a new natural product, named as guan-fu base P, its 1 H-NMR and 13 C-NMR data are reported first inthis paper.
