THE EXPRESSION OF GLUTAMATE TRANSPORTER IN PLASTIC ASTROCYTES IN FOCAL CEREBRAL INFARCT
- VernacularTitle:局灶性脑梗死引起谷氨酸转运体在星形胶质细胞的表达
- Author:
Guangyun ZHANG
;
Li DUAN
;
Zhiren RAO
;
Yuhong CAO
- Publication Type:Journal Article
- Keywords:
Focal cerebral ischemia;
Astrocyte;
Plasticity;
Glutamate transporter;
Immunchistochemistry;
Immunofluorescence;
Rat
- From:
Acta Anatomica Sinica
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of plastic astrocytes in focal cerebral infarct. Methods Immunohistochemical and double immunofluorescence techniques were used in the study. Results The astrcytes positive for glial fibrillary acidic protein(GFAP) occurred in the periinfarct area appeared hypertrophy and proliferation,specially on their processes and formed a network,and the processes oriented toward the infarct center from the periinfarction.The expression of excitatory amino acid transporter 1( EAAT1) increased in the penumbra area of cerebral infarct and manifested spot and fibre.The confocal laser scanning microscopic analysis showed the double staining for EAAT1 and GFAP.Conclusion The plastic astrocytes might participate in the pathological process of cerebral infarct recovery by enhancing the expression of EAAT1.;
