Clinical analysis of 10 cases of connective tissue diseases with lung bullae
- VernacularTitle:结缔组织病合并肺大泡十例临床分析
- Author:
Dong XU
;
Fengchun ZHANG
;
Jingyun LI
- Publication Type:Journal Article
- Keywords:
Connective tissue diseases;
Pulmonary alveoli;
Pulmonary disease;
Meta analysis
- From:
Chinese Journal of Rheumatology
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To substantiate the relationship between connective tissue diseases and lung bullae. Method In 10 years, 70 patients with lung bullae were admitted to internal medicine inpatient wards of Peking Union Medical College Hospital, among which 12 connective tissue diseases were diagnosed. Two cases were excluded because their lung bullae was secondary. Results Six cases were Sj?觟gren′s syndrome (SS), two cases were vasculitis [one Takayasu disease and one was polyarteritis nodosa (PAN)], one was rheumatoid arthritis (RA) and one was undifferentiated connective tissue disease (UCTD). Symptoms of respiratory system were present in the patients with pulmonary interstitial fibrosis (five cases) and pulmonary amyloidosis (one case). Pulmonary function tests showed restrictive ventilatory dysfunction and obstriction of small airway (two cases), diffusion dysfunction (one case), restrictive ventilatory dysfunction (one case). A trans-bronchial lung biopsy specimen showed thickening of alveolar septa, chronic inflammation, proliferation of fiberous connective tissue and inflammatory cell infiltration. Conclusion Connective tissue diseases may result in lung bullae because they cause narrow of small airways.It is definitive in the relationship between SS and lung bullae, but further study needs to be done to clarify the relationship between other connective tissue diseases and lung bullae.
