The effects of serotomin on ionic channels currents and membrane potentials of the guinea pig proximate colon myocytes
- VernacularTitle:5-羟色胺对结肠平滑肌细胞膜通道电流和膜电位的影响
- Author:
Long XU
;
Baoping YU
;
Mingkai CHEN
- Publication Type:Journal Article
- Keywords:
Serotonin;
Ionic channel;
Action potential;
Resting potential;
Colonic myocytes
- From:
Chinese Journal of Digestion
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of serotonin(5-HT) on the ionic channels currents and membrane potentials of single guinea pig proximate colon myocytes. Methods Cell images before and after contraction were captured and analyzed with an imag e analysis software. Channels currents, action potential (AP) and resting potent ial (RP) were recorded with an EPC-9 amplifier. Results The direct actions of 10 ?mol/L 5-HT to myocytes resulted in followin g effects: Firstly, the exogenous stimulated peak values of AP reduced to 60%?7 .3%(n=7,P
