The research of influence and related mechanism of obesity on prostatitis in rats

VernacularTitle:肥胖对大鼠前列腺炎性反应的影响及其相关机制
Author: Shixue LIU ; Ke LI ; Bin XIE ; Houbin ZHANG
Publication Type:Journal Article
Keywords: rats; prostatitis; obesity; inflammatory factor
From: Chongqing Medicine 2014;(4):469-470,473
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of high fat diet induced obesity on rat prostatitis and assesses the metabolic fea-tures .Methods The normal diet group ,high-fat diet group and the positive control group were established according to the experi-mental requirements .Obesity model was established due to high-fat-diet feed .Microscopy was performed to analyze Lecithin density and leucocyte count .IL-6 and IL-8 Release level in the prostatic fluid were measured with ELISA (enzyme-linked immunosorbent as-say) kits according to the manufacturer′s directions .IL-6 and IL-8 mRNA levels of prostate were measured by real time PCR .Re-sults Compared with normal diet group ,high-fat diet group tended to be obesity obviously in 5 weeks of high-fat diet .The inci-dence rate of prostatitis in high fat diet group was significantly higher than that of control group ,and high-fat diet group had higher IL-6 and IL-8 releasing and mRNA levels .Conclusion High-fat diet could increase incidence of prostatitis in rat .The effect is par-tially due to IL-6 and IL-8 releasing and expression .