Oxidative damage of parental drug-sensitive KB cells and multidrug resistant KBv200 cells mediated by anthraquinone derivatives
- VernacularTitle:大黄素蒽醌衍生物介导KB及KBv200细胞氧化损伤的研究
- Author:
Yan DING
;
Yongju LIANG
;
Yu LU
;
Liming CHEN
;
Yanfang LI
;
Lianquan GU
;
Liw FU
- Publication Type:Journal Article
- Keywords:
anthraquinone derivatives;
reactive oxygen species (ROS);
mitochondrial membrane potential (?? m);
antitumor
- From:
Chinese Traditional and Herbal Drugs
1994;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). The generation of ROS increased obviously after the cells were incubated with them for 12 h, and the increase of ROS reached the peak treated for 24 h. The levels of ?? m were time-dependently decreased after treating with four compounds for 12, 24, and 48 h. Conclusion The grouth of both MDR KBv200 cells and parental drug-sensitive KB cells were inhibited to the treatment of four anthraquinone derivative in vitro. The mechanism of their effects is associated with the increase of the cellular ROS level and the decrease of ?? m.
