Effect of flavonoid from Erysimum cheiranthoides on arrhythmia and acute toxicity
- VernacularTitle:桂竹糖芥黄酮总苷的抗心律失常作用及其急性毒性研究
- Author:
Xiaodan ZHANG
;
Lin LIU
;
Shaohua JIA
- Publication Type:Journal Article
- Keywords:
flavonoid from Erysimum cheiranthoides L.;
arrhythmia;
ECG;
LD 50
- From:
Chinese Traditional and Herbal Drugs
1994;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To study the anti-arrhythmia effect and acute toxicity of flavonoid from Erysimum cheiranthoides L. Methods To study the anti-arrhythmia of the flavonoid by determination of the ECG of rabbits. To study the acute toxicity effect of the flavonoid by Karber's method. Results The results showed that the flavonoid could remedy to tachycardia caused by Adriamycin and it could remedy to bradycardia caused by Verapamil. Acute toxicity showed that LD 50 of flavonoid is 311.7 mg/kg, 95% CI is 289.9—339.5 mg/kg. Conclusion The flavonoid can rectify tachycardia due to various reasons with very little toxicity.
