Effects of Weishu Powder on Acute Liver Injury Induced by Carbon Tetrachloride in Mice
- VernacularTitle:胃舒散对四氯化碳性肝损伤小鼠的影响
- Author:
Xukai LIN
;
Senyuan XU
;
Yipeng ZHANG
;
Tingliang ZHENG
;
Wei ZHANG
- Publication Type:Journal Article
- Keywords:
WEISHU POWDER/therapeutic use;
LIVER/injury;
DISEASE MODELS, ANIMAL;
MICE
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the effect of Weishu Powder (WP) on acute liver injury induced by carbon tetrachloride (CCl_4) in mice. 【Methods】 Fifty mice were randomized to normal control group (group A), model group (group B), bifendate pills group (group C), low-dose WP group (group D) and high-dose WP group (group E). The mice in the above groups were fed with the corresponding drugs by gastric infusion for 7 days. On the 8th day of feeding, the mice except those in group A were given 0.5% CCl_4 peanut oil solution (10 mL/kg) by intraperitoneal injection. Sixteen hours later, liver weight, serum level of alanine aminotransferase (ALT), malondialdehyde (MDA) content and necrotic focus amount in the liver were observed. 【Results】 As compared with the normal group, liver weight, serum ALT level and necrotic focus amount were increased in model mice with CCl_4-induced acute liver injury (P
