Intraocular penetration of levofloxacin in rabbit eyes following topical and subconjunctival administration
- VernacularTitle:左旋氧氟沙星滴眼及球结膜下注射的兔眼通透性比较
- Author:
Hang SUN
- Publication Type:Journal Article
- Keywords:
Levofloxacin;
Drug distribution;
Pharmacokinetics;
High performance liquid chromatography
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the ocular tissue concentrations and pharmacokinetic parameters in rabbit's eyes after topically and subconjunctivally administrated with levofloxacin (LVFX).Methods:The concentrations of LVFX in the cornea,aqueous humor,iris-ciliary body,lens and vitreous at different times were measured by high performance liquid chromatography after 0.3% LVFX were topically and subconjunctivally administrated into rabbits.Results:The penetration of LVFX into the cornea,iris-ciliary body,lens and vitreous after subconjunctival injection was significantly higher than that of topically applied one( P
