The expression of cyclin kinase inhibitor P21~(WAF1) and P27~(KIP1) in children with acute lymphoblastic leukemia
- VernacularTitle:儿童急性淋巴细胞白血病P21~(WAF1)、P27~(KIP1)蛋白表达及其临床意义
- Author:
Yongchun SU
- Publication Type:Journal Article
- Keywords:
Leukemia;
Cyclin kinase inhibitor;
Child;
Cell cycle
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To probe the expression of P21 WAF1 and P27 KIP1 in children with acute lymphoblastic leukemia (ALL) and its clinical significance.Methods:The method of immunocytochemistry is used to estimate the expression of P21 WAF1 and P27 KIP1 .Both percentage and intensity of positive cells were counted.Results:The results showed that the positive ratio of P21 WAF1 in ALL samples was 9.1% (2/22) and P27 KIP1 was 50%(11/22).The trends of higher expression of P21 WAF1 and P27 KIP1 were noted in follow-up study on eight patients with ALL.Most of the P27 KIP1 positive cells were pigmented in nucleus in the control group while pigmented in both nucleus and plasma in the studied patients.Conclusion:P21 WAF1 ,P27 KIP1 may be a marker for evaluation of therapeutic effects.
