Study of the effect and the security of liver ultrasonography with hydrogen peroxide affused by rabbits recta
- VernacularTitle:双氧水直肠灌注肝脏声学造影的有效性和安全性研究
- Author:
Liping LIU
- Publication Type:Journal Article
- Keywords:
Hydrogen peroxide;
Affusion;
Ultrasonography;
Effect;
Security
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of liver ultrasonography and the security to rabbits with hydrogen peroxide(H 2O 2) affused by rectum.Methods:48 rabbits were divided into 4 groups according to different H 2O 2 concentrations,and each group was divided into 4 groups according to different H 2O 2 dosages. Each rabbit was affused with H 2O 2 by rectum,then the effect of liver ultrasonography was observed,and the damages to the tissues of rabbits were pathologically checked.Results:The liver structure could be clearly developed with 1% H 2O 2 10ml affused,and the liver gray value increased with the H 2O 2 concentration increased.The time from affusion to develop was shortened and the duration of high echo was prolonged.But at same H 2O 2 concentration,the time to develop was not significantly different with the H 2O 2 dosage increased,and the high echo was decreased more slowly.The average survival time of rabbits was significantly negatively correlated to the H 2O 2 concentration(?=-0.99),while the damage degree was significantly positively correlated (?=+0.99).Conclusion:H 2O 2 affusion can induce damage to tissues and microcirculation,while produce better liver ultrasound image,so it is important to chose suitable H 2O 2 concentration and dosage,to extend its clinical application.
