Effect of Biejia Jian in Preventing Rat Hepatic Fibrosis
- VernacularTitle:鳖甲煎汤抗大鼠肝纤维化作用
- Author:
Weihong KUANG
;
Jianhua LI
- Publication Type:Journal Article
- Keywords:
Hepatic fibrosis;
Biejia Jian;
Disease models,animal
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Biejia Jian (BJ) in preventing rat hepatic fibrosis. Methods Rat models with hepatic fibrosis were established by abdominal subcutaneous injection of 45 %carbon tetrachloride (CCl4) and olive oil. Fifty Wistar rats were randomly divided into 4 groups: model group (treated with normal saline),small-dosage BJ group (6.25 g/kg BJ), moderate-dosage BJ group (12.5 g/kg BJ) and large-dosage BJ group (25.0 g/kg BJ). The treatment lasted 10 weeks. On the 11th week, rats eyes were removed to get blood sample. The biochemical parameters of blood were detected and HE staining was applied for the pathological examination of liver. Results BJ decreased the serum levels of ALT,AST,HA, LN and PC III in rats, no pseudo-lobules found in the BJ groups. Proliferation of fibrous tissue was mild and Limited and fatty degeneration of hepatocytes were slight in moderate-dosage and high-dosage BJ groups as compared with the small-dosage BJ group.Pathological changes in BJ groups were significantly improved (P
