Studies on Super Fine Crushing Technique in Increasing Dissolution Rate of Sunshang Capsule
- VernacularTitle:超微粉碎技术提高损伤胶囊溶出度的研究
- Author:
Hua JIANG
;
Huaqiang ZHAN
- Publication Type:Journal Article
- Keywords:
Sunshang Capsule;
Super fine crushing;
Dissolution rate;
Notoginsengside R1;
HPLC
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of super fine crushing technique on dissolution rate of Sunshang Capsule (SC). Methods With the dissolution of active components and notoginsengside as the markers, the dissolution rate in Sunshang Capsule and Sunshang powder which were prepared by super fine crushing method and fine crushing method respectively was compared by TLC and HPLC. Results The stain of Sunshang Capsule was bigger and darker than that of Sunshang Powder, time-limited dissolution of SC was 4.66 %higher and the content of notoginsengside R1 was 6 %higher than those of Sunshang Powder. Conclusion Super fine crushing technique can increase the dissolution rate of SC and this will supply evidence for the process of SC preparation.
