Relationship between non-alcoholic fatty liver disease and cardiovascular events in type 2 diabetes
10.3760/cma.j.issn.1008-1372.2014.02.008
- VernacularTitle:非酒精性脂肪肝病与2型糖尿病患者心血管事件的关系
- Author:
Xianghua ZHANG
;
Xiaoyue WANG
;
Changqing LUO
;
Lu XU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2/complications;
Fatty liver;
Cardiovascular diseases/complications
- From:
Journal of Chinese Physician
2014;(2):173-174,179
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether the non-alcoholic fatty liver disease ( NAFLD) can independently increase the risk of cardiovascular events in type 2 diabetes .Methods The cardiovascular endpoints were observed after 5 years follow up for fat liver group (46 cases, patient with fat liver and with diabetes more than 10 years), non-fatty liver group (50 cases, patients without fatty liver disease and with diabetes more than 10 years), and normal glucose group (46cases, patient with NAFLD and with normal glucose) in the same demographic characteristics.Results ⑴ Patient status before enrollment: The body mass index (BMI), and blood glucose levels in fat liver group and non-fatty liver group were higher than normal glucose group , while the high-density lipopro-tein cholesterol ( HDL-C) was lower than normal glucose group ( P <0.05 ) .There is no significant difference among three groups in blood pressure and triglyceride ( TG) level ( P >0.05 ) .⑵After 5 years observation:The BMI , blood glucose , and TG levels in fat-ty liver disease group were significant higher than other two groups , while the HDL-C was lower than other two groups .The glucose control level of fat liver group was higher than normal glucose group ( P <0.05 ) .⑶After 5 years observation:The incidence of cardi-ovascular events of fat liver group was higher than other two groups ( P <0.05 ) .There is no significant difference between the normal glucose group and non-fatty liver group in the incidence of cardiovascular events ( P >0.05 ) .Conclusions NAFLD can independent-ly increase the risk of cardiovascular events in type 2 diabetes.
