A Comparison of the Clinical Characteristics of Kawasaki Disease in Children from Taizhou
- VernacularTitle:大年龄组与低年龄组儿童川崎病临床特点的比较研究
- Author:
Youmin ZHENG
;
Hailing FAN
;
Chunhong XIE
- Publication Type:Journal Article
- Keywords:
KD;
age;
coronary arterial disease;
inflammtory factors;
gamma globin;
clinical characteristics
- From:
Journal of Zhejiang Chinese Medical University
2014;(4):419-421,422
- CountryChina
- Language:Chinese
-
Abstract:
[Objectives] To evaluate characteristics of Kawasaki disease(KD) in children younger than 5 years old in comparison with older than 5 years old, and to improve the knowledge of clinicians on KD in older children. [Method] The clinical characteristics and treatment of Kawasaki disease from January, 2004 to May,2011 were analyzed retrospectively and summarized .[Results] A total of 158 patients were included in this study, 39 patients(24.7%) were ≥5 years old and 79 patients(75.3%) were<5 years old. The older children seemed to have longer total fever duration, pre-intravenous immunoglobulin(IVIG) and post-IVIG fever duration and higher coronary artery disease(23.08% vs.8.40%) than the younger children, and the incidence rate of incomplete KD was higher in younger infant. But there was no difference in effect of IVIG ,incidence of conjunctival hyperemia, extremity hardness, cervical lymphadenopathy and rash, etc(P>0.05). There was statistical difference in erythrocyte sedimentation rate(ESR), hemoglobin(Hb) and white blood cell(WBC) count between 2 groups(P<0.05).The expression of inflammation factor in acute phase of older children was higher than the younger children(P<0.05). [Conclusions] Older patients had a higher prevalence of KD and coronary artery abnormalities than the younger patients. The occurrence of coronary artery might be related to more marked inflammatory response.
