Application of Shandong Yaosheng 1 + 1 (Ⅲ) clarificant in clarifying processof Anti-flu Nose Drops
- VernacularTitle:Ⅲ型山东药圣1+1澄清剂用于抗流感滴鼻剂的澄清工艺
- Author:
Huizong ZHANG
;
Mingyun PAN
;
Ruoshi ZHANG
;
Daming LI
- Publication Type:Journal Article
- Keywords:
Anti-flu Nose Drops (AND);
Shandong Yaosheng 1 + 1 ( I ) clarificant;
gardenoside;
magnolin;
HPLC;
TLC
- From:
Chinese Traditional and Herbal Drugs
1994;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To investigate the process of flocculation impurity removal for the Anti-flu Nose Drops (AND). Methods Five kind of effective factors on flocculation impurity removal with the index of clarifying results were studied. Comparative tests for Shandong Yaosheng 1 + 1 (Ⅲ) clarificant, 50% alcohol precipitation, and 75% alcohol precipitation were performed with the quantitative index of gardenoside contents, the qualitative index of magnolin and gardenoside TLC chromatograms. The optimum process condition was selected out. Results Under the optimum process condition of flocculation impurity removal, gardenoside contents in the flocculation group is higher than those in 50% , 75% alcohol groups. TLC chromatograms showed that the spots of flocculation group are the same as those in the original liquid group. Conclusion Shandong Yaosheng 1 + 1 (Ⅲ) clarificant has following advantages; high reserved rate of active components, simple operation, cheap cost, stable process, which is a ideal method for the impurity removal.
