Influence and Curative Effect Observation of Carvedilol on Serum Matrix Metalloproteinase -2, 9 and 10 (MMP-2, 9 and 10) in Patients with Chronic Congestive Heart Failure
- VernacularTitle:卡维地洛对慢性充血性心力衰竭患者血清基质金属蛋白酶-2、9、10水平的影响及疗效观察
- Author:
Jinjin ZHU
;
Zhikui SUN
- Publication Type:Journal Article
- Keywords:
Chronic congestive heart failure;
Carvedilol;
Matrix metalloproteinase-2;
Matrix metalloproteinase-9;
Matrix metallo-proteinase -10
- From:
China Pharmacist
2014;(5):816-817,818
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the influence and curative effect of carvedilol on serum matrix metalloproteinase -2, 9 and 10 (MMP-2, 9 and 10) in the patients with chronic congestive heart failure (CHF). Methods:Totally 76 patients with CHF were select-ed and randomly divided into the observation group and the control group. All the patients were given routine medical treatment, inclu-ding cardiotonic treatment ( digoxin) , diuresis ( thiadiazide) , vascular dilation ( nitrate ester) and so on. The patients in the observa-tion group were additionally given carvedilol for 6 months. The changes of serum MMP-2, 9 and 10 levels in the patients before the treatment and 6 months after the medical treatment were observed, and the curative effect and safety were studied as well. Results:Af-ter the 6-month medical treatment, the serum MMP-2, 9 and 10 levels in all the patients were obviously declined(P<0. 05), and the declining rates in the observation group were much higher than those in the control group(P<0. 05). Meanwhile, the total clinical effi-ciency of the observation group was 94. 74%, which was higher than that of the control group (78. 95%) (P<0. 05). Conclusion:Carvedilol has favorable curative effect and safety in the treatment of CIF, and the underlying mechanism may be relative to the de-crease of serum MMP-2, 9 and 10 levels.
