DETECTION OF Nogo-A PROTEOLYTIC FRAGMENT DURING CNS INJURY
- VernacularTitle:中枢神经系统损伤过程中Nogo-A降解片段的检测
- Author:
Chunxia ZHENG
;
Weilin JIN
;
Gong JU
- Publication Type:Journal Article
- Keywords:
Nogo-A;
Injury;
Ischemia;
Western blot;
Rat
- From:
Acta Anatomica Sinica
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect Nogo-A proteolytic fragment in CNS injury models and investigate its proteolytic mechanism as well as potential functions. Methods Western blot was performed to detect Nogo-A proteolytic fragment after spinal cord transection,brain ischemia and KA-induced cerebral cortex injury in rats. Results We detected Nogo-A proteolytic fragment in spinal cord transection and brain ischemia models,whereas no Nogo-A proteolytic fragment was found in KA-induced cerebral cortex injury model.Conclusion\ CNS mechanical and ischemic injury may induce the degradation of Nogo-A by certain mechanisms.
