The significance of anti-p68 antibody in rheumatoid arthritis
- VernacularTitle:抗p68抗体的检测及其在类风湿关节炎中的意义
- Author:
Xiaoyun SUN
;
Rong MU
;
Zhanguo LI
- Publication Type:Journal Article
- Keywords:
Arthritis, rheumatoid;
Anti-p68 antibody;
Diagnostic techniques and procedures
- From:
Chinese Journal of Rheumatology
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic specificity and sensitivity of anti-p68 antibody in rheumatoid arthritis (RA), and to analyze the relationship between anti-p68 antibody and the activity of RA . Methods Anti-p68 antibody was tested in the serum of 183 RA patients and 195 controls by indirect immunofluorescence (IIF). The clinical characteristics of RA between anti-p68 positive group and negative group were compared. Results ① The positive rate of anti-p68 antibody was 67.8% (124/183) in RA, 14.9% (17/114) in other rheumatic diseases and none in normal controls (0/81). Anti-p68 antibody was different from other auto-antibodies found in RA. ② Its sensitivity was 67.8% and specificity was 91.3% for RA, positive prediction rate was 87.9% and negative prediction rate was 75.1%. ③ There was statistic difference between the positive group and negative group in disease duration, RF and degree of X-ray changes. Conclusion ① Anti-p68 antibody is a new and specific serum maker for diagnosis of RA. ② The antibody is correlated with disease duration, RF and X-ray changes.
