Correlation between local hormones and CD_(36) transcription level in women with polycystic ovary
- VernacularTitle:多囊卵巢患者卵巢局部激素与CD_(36)转录水平的相关性研究
- Author:
Liangqing YAO
;
Jianquan KUANG
;
Dongzi YANG
;
Lin LI
;
Yingming HE
;
Guangyi LI
;
Lushi CHEN
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Antigens, CD_(36);
Testosterone;
Insulin
- From:
Chinese Journal of Obstetrics and Gynecology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect CD_(36) expressions in polycystic ovary (PCO), and to explore its correlation with local androgen and insulin at transcription level. Methods From August 2002 to February 2003, 12 patients with asymmetric PCO, 15 primary or secondary infertile patients without endocrine disorders and 8 polycystic ovary syndrome (PCOS) with bilateral PCO were recruited. Extraction of follicular fluid and detection of testosterone(T), dehydroepiandrosterone sulfate (DHEAS), insulin (INS) and androstenedione (A_2) were performed. Relative CD_(36) mRNA expression level of human ovarian inner thecal cells was analyzed by auto image analysis system (IAS) after RT-PCR. Results The level of CD_(36) mRNA expression in thecal cells was 0.24?0.07 in polycystic ovary of PCO group and 0.21?0.05 in bilateral ovaries of PCOS group, respectively, which were significantly lower than 0.83?0.13 in normal ovaries (P
