Preparation technique of irisquinone-hydroxypropyl-?-cyciodextrin inclusion complex with orthogonal design
- VernacularTitle:正交试验优化马蔺子素-羟丙基-?环糊精包合物的制备工艺
- Author:
Xuenong ZHANG
;
Xueying YAN
;
Lihuan TANG
;
Qian ZHANG
- Publication Type:Journal Article
- Keywords:
irisquinone;
inclusion complex;
ultraviolet spectrophotometer;
orthogonal design
- From:
Chinese Traditional Patent Medicine
1992;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To screen and optimize the preparation conditions of irisquinone-hydroxypropyl-?-cyclodextrin inclusion complex (Irisquinone-HP-?-CD) with stiring method. METHODS: The load-drug and recovery of irisquinone were adopted as the index, host-guest molar ratio, alcohol concentration and stiring rate as factors, have been investigated in the techniques of irisquinone-HP-?-CD. RESULTS: The load-drug and recovery of irisquinone-HP-?-CD were respective ( 15.79 ?0.22)% and ( 92.03 ?6.26)% by optimizing conditions which were host-guest molar ratio 2∶1, 90% EtOH and stiring rate 800r?min -1. At the same time, the dissolution test showed that irisquinone was faster released from inclusion complex than that from capsules and mixture dosage form. CONCLUSION: The optimizing techniques fit to prepare irisquinoe-HP-?-CD in industry.
