Protective effect of Buxinqi Capsule on the injury induced by ischemia and reperfusion in rat
- VernacularTitle:补心气胶囊在麻醉大鼠心肌缺血再灌注损伤模型中的保护作用
- Author:
Rong XU
;
Ling RU
;
Shifen GU
;
Hui CHEN
- Publication Type:Journal Article
- Keywords:
Buxinqi (BXQ);
myocardial ischemia;
reperfusion injury
- From:
Chinese Traditional Patent Medicine
1992;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the influence of Buxinqi Capsule (BXQ) on myocardial ischemia reperfusion injury in rats. METHODS: In this study, the experimental model was established by reperfusion for 60 minutes in rats after ligaturing left anterior descending coronary artery (LAD) for 30 minutes. Serum creatine phosphokinase (CPK), lactate dehydrogenase (LDH), superoxide dismutase (SOD) and malondialdehyodebis (MDA), area of myocardial infarction and occurrence of arrhymia were investigated. RESULTS: BXQ significantly decreased level of CPK and LDH and MDA, and obviously improved the activity of SOD, decreased reperfusion arrhythmias and arrhythmias severity index (ASI), and decreased the area of myocardial infarction. CONCLUSION: BXQ has protective effect on the damage of myocardia ischemia reperfusion in rats
