Abnormal expression of CD154 in the peripheral blood B lymphocytes from lupus patients and its implication in the pathogenesis
- VernacularTitle:CD154在活动期系统性红斑狼疮B淋巴细胞中的表达
- Author:
Xuan ZHANG
;
Ying JIANG
;
Wen ZHANG
;
Fulin TANG
- Publication Type:Journal Article
- Keywords:
B lymphocytes;
Lupus erythematosus, systemic;
CD154
- From:
Chinese Journal of Rheumatology
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the expression level of CD154 in systemic lupus erythematosus(SLE) and its role in the pathogenesis. Methods CD154 were detected by flow cytometry in CD19+ peripheral blood lymphocytes from 16 active lupus patients and 14 healthy controls. Effects of anti-CD154, on the proliferation and IgG secretion by peripheral B lymphocytes were also observed. Results ① The positive rates and mean fluroscence intensity of CD154 in peripheral blood B lymphocytes from active lupus [(36?17)%,364?238] were significantly higher than from normal controls[(10?8)%, 124?97], (P
