Mechanism of Jianxin Pinglu Pill in Counteracting Arrhythmia
- VernacularTitle:健心平律丸抗心律失常的机理研究
- Author:
Xuping HE
;
Dongfeng CHEN
;
Jianhong ZHENG
;
Shaohui DU
- Publication Type:Journal Article
- Keywords:
JIANXIN PINGLU PILL/therapeutic use;
ARRHYTHMIA/TCD therapy;
MYOCARDIAL ISCHEMIA/TCD therapy;
CONNEXIN 43/drug effects
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
[ Objective ] To investigate the mechanism of Jianxin Pinglu Pill (JPP) in counteracting arrhythmia. [Methods] Ninety rats were randomized into 3 groups: model (normal saline), high-dose JPP (1.6 g/kg) and low-dose JPP (0.8g/kg) . The treatment lasted 7 days. Rat models with myocardial ischemia /repermsion were established by blocking left coronary artery. Ⅱ lead of electrocardiogram was recorded, connexin 43 (Cx 43) was detected by immunohistochemical assay. The effect of JPP on incidence of arrhythmia, death rate and the expression of connexin 43 in the myocardium was observed. [Results] JPP could decrease the incidence of arrhythmia and death rate obviously and enhance the expression of connexin 43 in myocardium. [ Conclusion ] JPP can counteract the damage of myocardial ischemia /reperfusion to enhance Cx 43 expression, and this is one of its possible mechanism.
