Experimental Studies on Zhenchan Ning for Parkinson's Disease
- VernacularTitle:震颤宁治疗帕金森病的实验研究
- Author:
Weifeng ZHU
;
Rongjing LUO
;
Liping ZHOU
;
Bingyan TAN
- Publication Type:Journal Article
- Keywords:
PARKINSON'S DISEASE/TCD therapy;
RECEPTOR, DOPAMINE;
ZHENCHAN NING/therapeutic use;
DISEASE MODELS, ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
[ Objective ] To investigate the mechanism of Zhenchan Ning (ZN) for Parkinson's Disease ( PD). [Methods] Rat models of PD were established by striatal infusion of 6-hydroxy dopamine (6-OHDA) . Effect of ZN on rat rotating behavior was observed, and the contents of dopamine ( DA), homovanillic acid (HVA), superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH) and glutathione peroxidase (GSH-PX) in blood and corpus striatum were also detected. [Results] As compared with those before treatment, high-dose ZN could improve the rotating behavior and decrease the rotating frequency ( P 0.05), but could decrease serum MDA content (P
