Mechanism of Ruangan Granule in Counteracting Immune Liver Fibrosis in Rats
- VernacularTitle:软肝颗粒抗免疫性肝纤维化作用机制研究
- Author:
Xiaomei ZHOU
;
Daqiao ZHOU
;
Xiaozhou ZHOU
;
Yanping QI
;
Hui GAO
;
Jinsong HE
- Publication Type:Journal Article
- Keywords:
RUANGAN GRANULE/therapeutic use;
CIRRHOSIS, LIVER/TCD therapy;
TRANSFORMING GROWTH FACTOR ?/blood;
LIVER/pathology
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To study the mechanism of Ruangan Granule (RG) in counteracting the experimental liver fibrosis and cirrhosis in SD rats. [Methods] As compared with colchicines, effect of RG in small and large dosages on serum transforming growth factor ? (TGF ?1 ), hydroxyproline (Hyp), collagen Ⅰ and Ⅲ , hepatic function and hepatic pathology were observed in rats. [ Results ] Both RG and colchicines could decrease serum levels of alanine aminotransferase (ALT) and alkaline phosphatase (AKP) and increase serum levels of total protein and albumin in rats with liver fibrosis induced by bovine serum albumin (P 0.05). Effect of large-dosage RG in improving hepatic pathology was better than that of colchicines. [Conclusion] RG has an inhibitory effect on the formation of liver fibrosis and cirrhosis. Its mechanism may be related to the improvement of hepatic function, decrease of serum TGF ft , collagen Ⅰ and Ⅲ and Hyp levels.
