Effect of Ningxian Granule on Brain-derived Neurotrophic Factor Protein Expression in Rats with Pentylenetetrazol- Induced Epilepsy
- VernacularTitle:宁痫冲剂对戊四唑致痫大鼠脑源性神经营养因子蛋白表达的影响
- Author:
Liping ZHANG
;
Zhuo FANG
;
Yingshi JIANG
;
Ke YANG
;
Li WU
;
Zhiming ZANG
- Publication Type:Journal Article
- Keywords:
EPILEPSY/TCD therapy;
NINGXIAN GRANULE/pharmacology;
BRAIN-DERIVED NEUROTROPHIC FACTOR;
BRAIN/pathology;
DISEASE MODELS ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
[ Objective ] To investigate the mechanism of Ningxian Granule (NG), a compound prescription with lucidity-ascending and turbidity-descending actions. [ Methods ] Forty SD rats were randomized into 5 groups: A (normal), B (model), C (low-dose NG, 5 g/kg), D (high-dose NG, 10 g/kg) and E (phenobarbital, 60 mg/ kg). Except Group A, the others were epileptic rats induced by pentylennetetrazol (PTZ, 35 mg/kg). NG and phenobarbiatal were given to different groups accordingly, once a day for 4 weeks. The effects of NG on brain-derived neurotrophic factor (BDNF) protein expression was observed by using immunohistochemistry technique. [Results] The number of positive neuron increased both in the hippocampus and cerebral cortex of epileptic rat brain (P
