Effect of Kun'an Granule on Serum Hormone Level in Rats with Hyperprolactinemia
- VernacularTitle:坤安冲服剂对高泌乳素血症大鼠血清激素水平的影响
- Author:
Zhiling ZHANG
;
Jufang LIU
;
Huilin LI
;
Hengxia ZHAO
- Publication Type:Journal Article
- Keywords:
KUN'AN GRANULE/therapeutic use;
HYPERPROLACTINEMIA/TCD therapy;
PROLACTIN/blood;
FOLLICLE-STIMULATING HORMONE/blood;
LUTEINIZING HORMONE/blood;
ESTROGEN/blood;
TESTOSTERONE/blood;
DISEASE MODELS, ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the effect of Kun'an Granule (KG) on serum hormone level in rats with hyperprolactinemia [ Methods ] Rats were randomized to five groups: group A ( mimic operation) , group B (model control), group C (bromocriptine), group D (low-dose KG) and group E (high-dose KG). Except group A, the other four groups were implanted with pituitary for modeling. Group C was treated with bromocriptine 1 mg/kg, group D with gastric infusion of KG 4 g/kg and group E with KG 12 g/kg. The treatment lasted 34 days. Serum levels of prolactin (PRL), testosterone (T), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estrogen (E2) were detected before and after treatment and the differences between groups were compared. [ Results ] Serum PRL and T levels were increased and LH, FSH and E2 levels decreased in group B (P
