Interleukin-4 Receptor Expression on Human Renal Cell Carcinoma Cell Lines by a Reverse Transcription-Polymerase Chain Reaction.
- Author:
Jun CHEON
1
;
Dong Joon CHUNG
;
Jong Bo CHOI
;
Sung Kun KOH
;
Jeong Won SOHN
Author Information
1. Department of Urology, College of Medicine, Korea University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Renal cell carcinoma;
Interleukin-4;
Receptor;
Gene expression;
Reverse transcription-polymerase chain reaction
- MeSH:
Carcinoma, Renal Cell*;
Cell Line*;
Cell Line, Tumor;
Gene Expression;
Humans*;
Interleukin-4*;
Receptors, Interleukin-4;
RNA, Messenger
- From:Korean Journal of Urology
1995;36(2):121-127
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Recently interleukin-4 (IL-4) has been suggested to be a promising therapeutic agent for the malignant tumors of both murine and human origin. The effect of IL-4 is mediated by IL-4 receptor (IL-4R), which has been shown to be expressed in many normal and tumor cell lines. We herein tested two cell lines of human renal cell carcinoma (RCC), Caki-1 and CURC-II, for the expression of IL-1R gene. On the reverse transcription-polymerase chain reaction study, both cell lines expressed IL-4R mRNA. The present study suggests that it would be worthwhile to investigate the anti-tumor effect of IL-4 on Caki-l and CIJRC-II, which may help to develop new therapeutic strategies for RCC using IL-4.
