Analysis of magnetic resonance spectroscopy in superacute cerebral infarction in the rabbit
- VernacularTitle:超急性脑梗塞的磁共振波谱分析
- Author:
Shijiang ZHONG
- Publication Type:Journal Article
- Keywords:
Superacute cerebral infarction;
MRS;
Rabbit
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the metabolic characteristics and the changes with lapse of time in superacute cerebral infarction in order to provide pathophysiological evidences for thrombolytic therapy and the use of neuroprotective drugs in superacute stage.Methods:12 healthy rabbits were randomly divided into two groups:sham operative group (5 rabbits)and occlusion of middle cerebral artery (MCAO) group (7 rabbits).The rabbits with MCAO were scanned with 1.5T MRI unit.The infarct regions and their mirror image regions were analyzed by probe 2000 software package of multi-voxel ~1 H magnetic resonance spectroscopy (~1H-MRS) at 0.5,1,2,3,4 and 6 hours respectively after MCAO.Results:(1)sham operative group:bilateral metabolites were symmetrically distributed,and N-acetylaspartate (NAA)/choline containing compounds (Cho),phosphocreatine and creatine(Pcr+cr)/Oho showed no significant difference(P
