Experimental study of improved cardiac remodeling and cardiac dysfunction by Simvastatin
- VernacularTitle:辛伐他汀改善急性心肌梗死后心室重塑与心功能的实验研究
- Author:
Qiaoying YUAN
- Publication Type:Journal Article
- Keywords:
Simvastatin;
Myocardial infarction;
Cardiac remodeling;
Nitric oxide
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the beneficial effects of Simvastatin on cardiac remodeling and cardiac dysfunction after myocardial infarction and its possible mechanisms.Methods:Simvastatin was administered to the rats with myocardial infarction rats by left anterior descending coronary artery ligation.After 8 weeks,cardiac remodeling was observed through right ventricular weight index (RVWI),and left ventricular weight index (LVWI).Changes in hemodynamics were observed.The activity of nitric oxide synthase (NOS) and inducible nitric oxide synthase (iNOS) in left ventricle and serum were measured.Results:In the rat model of myocardial infarction RVWI,LVWI increased and activity of NOS and iNOS in ventricle and serum decreased(P
