The effect of valsartan on TNF-? production in patients with congestive heart failure
- VernacularTitle:缬沙坦在体外对充血性心力衰竭患者血清TNF-?的影响
- Author:
Qihong CHEN
- Publication Type:Journal Article
- Keywords:
Congestive heart failure;
TNF-?;
NO;
Valsartan
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the change of serum tumor necrosis-? (TNF-?),nitric oxide (NO) in patients with congestive heart failure(CHF) in vitro and the effect of valsartan on TNF-? production in peripheral blood mononuclear cell(PBMC),and to assess the mechanisms of valsartan in treating CHF.Methods:Venous blood sumples were obtained from both CHF patients (n=12) and healthy volunteers(n=8).Serum TNF-? and NO were measured.PBMC was obtained from both the control and the patient groups.PBMC were cultured with 0,0.01,0.1,1 ?mol/L of valsartan in the presence of lipopolysaccharide.After 24 hours' incubation,TNF-? and NO were measured in the culture supernatants.Results:Serum TNF-? and NO were significantly higher than these of the control group(P
