A Comparative Study on the Mutagenicity of Natural Borneol and Synthetic Borneol
- VernacularTitle:一种新来源天然冰片与合成冰片的致突变性比较研究
- Author:
Yang LIU
;
Limin HU
;
Yilan LI
;
Xiang FAN
;
Rong DU
;
Boli ZHANG
- Publication Type:Journal Article
- Keywords:
Natural Borneol;
Synthetic Borneol;
Ames test;
Mutagenicity
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective&Methods The mutagenicity of natural Borneol and synthetic Borneol was studied by using Ames test.Results Natural Borneol and Synthetic Borneol in the dose range of 0.4～250.0 ?g/plate had no effect in reducing the reversion frequencies of Salmonella Typhimurium histidine auxotrophic mutant(TA97,TA98,TA100,TA102)whether if metabolic activation system(S9mix)existed or not.Moreover,the backward mutant colony had normal background.Conclusion Natural Borneol and Synthetic Borneol do not possess evident mutagenicity under experimental condition.
