Effects of Stilbene-glycoside on Learning and Memory and Inflammatory Reaction of Brain in Dementia Mice
- VernacularTitle:二苯乙烯苷对痴呆小鼠学习记忆及大脑炎性反应的影响
- Author:
Jin CHU
;
Cuifei YE
;
Lin LI
- Publication Type:Journal Article
- Keywords:
Stilbene-glycoside;
?-Amyloid;
Dementia;
Learning and memory;
Alzheimer's disease
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of 2,3,5,4'-tetrahydroxy stilbene-2-?-D-glycoside (TSG)on learning and memory and free radicals metabolism in mice with dementia induced by ?-amyloid(A?).Methods The mice models were established by injection of A?1-40 into the right lateral ventricle,and the treatment group was administered with TSG for 8 weeks by gastrogavage.Morris water maze and step-through test were performed in all the mice and then the mice were killed and radioimmunoassay was used to detect the content of interleukin-6(IL-6).Results The learning and memory in model mice were worse and the cortical IL-6 content increased compared to the normal control mice.TSG improved the learning and memory of A?-induced model mice and reduced cortical IL-6 content.Conclusion TSG could improve the learning and memory of dementia mice and decrease cortical IL-6 content,indicating a promising prospect in the treatment of dementia disease such as Alzheimer's disease.
