Influence of Gusongbao Capsule on the Bone Morphological and Blood Biochemical Indexes in Rats with Osteoporosis Induced by Vitamin A Acid
- VernacularTitle:骨松宝胶囊对维甲酸骨质疏松大鼠骨形态学和生化指标的影响
- Author:
Guilin ZHANG
;
Siyuan LIU
;
Guangyou REN
;
Jun LI
- Publication Type:Journal Article
- Keywords:
Gusongbao Capsule;
Osteoporosis;
Rat;
Vitamin A acid;
Bone morphology;
Biochemistry index
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the anti-osteoporosis effect of Gusongbao capsule (GC).Methods Osteoporosis rat models were induced by gastric infusion of vitamin A acid at a dose of 70 mg/kg for 14 days. The bone morphological and blood biochemical indexes and the amount of calcium and phosphorus in urine excreted every day were determined in both treatment group (treated with Gusongbao) and model control group.Results In the treatment group,the average width of bone trabecula,relative bone volume,average thickness of bone cortex,bone calcium,cell number in per unit area of bone trabecula,and the average gray degree of caput femoris and femoral shaft were higher than those in the moderate group. High dose (0.8 g/kg) and middle dose (0.4 g/kg) of GC increased bone phosphorus level and decreased urine calcium level markedly and high dose of GC also increased serum level of CT (P
