Expression and significance of P-glycoprotein in triple negative breast cancer
10.3760/cma.j.issn.1673-4203.2014.03.012
- VernacularTitle:三阴性乳腺癌中P-gp的表达及意义
- Author:
Xiaobin MA
;
Yafan SONG
;
Weili MIN
;
Shuai LIN
;
Huafeng KANG
;
Zhijun DAI
;
Xijing WANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Triple negative breast cancer;
P-glycoprotein;
Glycoproteins;
Recurrence;
Neoplasm metastasis
- From:
International Journal of Surgery
2014;41(3):181-184,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of P-glycoprotein in triple negative breast cancer (TNBC).Methods One hundred and seventy-one cases of breast invasive ductal carcinoma in our hospital were retrospectively analyzed.According to the expression of ER,PR,Her2,we categorized those paitents into triple negative breast cancer group (58 cases) and non triple negative breast cancer group (113 cases).The different expression of P-glycoprotein was detected by immunohistochemieal technology in two groups.We analyzed the relationship between the expression of P-glycoprotein and clinical and pathological features in TNBC,and investigated the effect of P-gp on the rate of recurrence and metastasis in 3 years.Results (1) The expression of P-gp in TN BC was significantly higher than that of NTNBC (53.45％ vs 37.17％) (P ＜ 0.05).(2) The expression of P-gp in TNBC was associated with TNM stage,histological grade,lymph node status and vascular invasion (P ＜ 0.05),but not with age and size of the tumor (P ＞ 0.05).(3) The rate of recurrence and metastasis in positive expression of P-gp in TNBC was 58.06％,which was significantly higher than negative expression of P-gp in TNBC (44.44％),but no statistically significant was found(P ＞ 0.05).Survival analysis showed that P-glycoprotein expression had no relationshiop to 3-year cumulative survival rate (P =0.161 ＞ 0.05).Conclusions The positive expression of P-gp in TNBC is associated with drug resistance and metastasis,but has no obvious significance to recurrence and metastasis,so as to 3-year cumulative survival rate.
