Clinical study on intratracheal instillation of sodium nitroprusside for treating persistent pulmonary hypertension of newborn
10.3969/j.issn.1671-8348.2014.11.012
- VernacularTitle:气管内滴入硝普钠治疗新生儿持续肺动脉高压的临床研究
- Author:
Nan WANG
;
Jinning ZHAO
- Publication Type:Journal Article
- Keywords:
nitroprusside;
persistent fetal circulation syndrome;
nitric oxide
- From:
Chongqing Medicine
2014;(11):1315-1316,1319
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect and safety of the intratracheal instillation of sodium nitroprusside for treating persistent pulmonary hypertension of newborn (PPHN) .Methods The intratracheal instillation of sodium nitroprusside was used to 19 cases of PPHN under the mechanical ventilation ,and the pulmonary arterial mean pressure(PAMP) ,arterial mean pressure(AMP) ,transcutaneous oxygen saturation(TcSaO2 ) of the right upper and left lower limb at the basic state ,30 ,60 ,120min after intratracheal instillation of sodium nitroprusside were respectively measured and compared .Results Among 19 cases of PPHN ,17 cases had the primary lung disease .Of 17 cases ,14 cases(82 .35% ) had significant decrease of PAMP after intratracheal instillation of sodium nitroprusside ,which was most significant at 30min after therapy and the difference was statistically significant compared with before therapy [(21 .30 ± 4 .200)mm Hg vs .(30 .30 ± 4 .20)mm Hg ,P<0 .05] ,but AMP between before and after therapy had no statistical difference [(56 .00 ± 3 .00)mm Hg vs .(55 .00 ± 6 .00)mm Hg ,P>0 .05] .Conclusion The intratracheal instillation of sodium nitroprusside is the safe ,effective and economic method for treating PPHN .
