CHANGES OF STAT3 EXPRESSION IN RETINA AFTER TRANSECTION OF OPTIC NERVE
- VernacularTitle:视神经切断术后视网膜内信号转导子与转录激活子STAT3蛋白的表达变化
- Author:
Meng LIU
;
Yan ZHANG
;
Baiyu CHEN
;
Enhua YU
- Publication Type:Journal Article
- Keywords:
STAT3;
Retina;
Axotomy;
JAK-STAT;
Hamster
- From:
Acta Anatomica Sinica
1957;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and distribution of protein STAT3 in the retina after optic nerve transection. Methods Immunocytochemistry, Western blot and computer image analysis techniques were used. Results After optic nerve transection, STAT3 levels in the retina was highly up-regulated, the peak of which appeared at day 1 postaxotomy, then decreased gradually to the normal level 5 days later. More translocations of STAT3 to the nucleus were seen.Conclusion JAK-STAT signal transduction pathway was involved in the pathological processes in the retinal after transection of the optic nerve.
